Boyle is the second son of Roger Boyle, 2nd Earl of Orrery, and his wife Lady Mary Sackville, daughter of Richard Sackville, 5th Earl of Dorset. He is educated at Christ Church, Oxford, and soon distinguishes himself by his learning and abilities. Like the first earl, he is an author, soldier and statesman. He translates Plutarch‘s life of Lysander, and publishes an edition of the epistles of Phalaris, which engages him in the famous controversy with Richard Bentley. He is a member of the Parliament of Ireland and sits for the Charleville constituency between 1695 and 1699. He is three times member for the town of Huntingdon and, upon the death of his brother, Lionel, 3rd earl, in 1703, he succeeds to the title.
Boyle enters the army, and in 1709 is raised to the rank of major-general and sworn one of Her Majesty’s Privy Council. He is appointed to the Order of the Thistle and appointed queen’s envoy to the states of Brabant and Flanders. Having discharged this trust with ability, he is created an English peer, as Baron Boyle of Marston, in Somerset. He inherits the estate in 1714.
Boyle becomes a Fellow of the Royal Society in 1706. In 1713, under the patronage of Boyle, clockmaker George Graham creates the first mechanical solar system model that can demonstrate proportional motion of the planets around the Sun. The device is named the orrery in the Earl’s honour.
Boyle receives several additional honours in the reign of George I but, having had the misfortune to fall under the suspicion of the government for playing a part in the Jacobite Atterbury Plot, he is committed to the Tower of London in 1722, where he remains six months, and is then admitted to bail. On a subsequent inquiry he is discharged.
Boyle writes a comedy, As you find it, printed in 1703 and later publishes together with the plays of the first earl. In 1728, he is listed as one of the subscribers to the Cyclopaedia of Ephraim Chambers.
Charles Boyle dies at his home in Westminster on August 28, 1731 and is buried in Westminster Abbey. He bequeaths his personal library and collection of scientific instruments to Christ Church Library. The instruments are now on display in the Museum of the History of Science, Oxford.